Check carefully and make sure that you have implemented the required versions in your SAP on VMware vSphere environment.
VMware Tools Version 10.3.0 Recall and Workaround Recommendations. 09/17/2018
VMware has been made aware of issues in some vSphere ESXi 6.5 configurations with the VMXNET3 network driver for Windows that was released with VMware Tools 10.3.0. As a result, VMware has recalled the VMware Tools 10.3.0 release. This release has been removed from the VMware Downloads page. VMware KB 57796.
Speculative-Execution Vulnerability CVE-2018-3646 08/14/2018
Intel published details on a new class of CPU speculative-execution vulnerabilities known as “L1 Terminal Fault” that can occur on current and past Intel processors. For VMware's mitigation strategy, see SAP Note 2680466.
Windows Server 2008 (R2) vNIC incompabilities 03/17/2018 The Security Updates KB4088875 and KB4088878 for Windows Server 2008 (R2) have incompatibility issues with VMs running on VMware vSphere. These patches replace the existing virtual network card (vNIC) with a new one, hide the pre-existing vNIC and do not persist or transfer the existing IP Address configuration to the new vNIC. For details, check this blog.
Meltdown and Spectre Vulnerabilities 01/05/2018 Like most other vendors, also VMware has released patches for the recently identified vulnerabilities in microprocessors, code named Spectre (CVE-2017-5753, CVE-2017-5715) and Meltdown (CVE-2017-5754).
Applications fail to start when using Open VMware Tools with SLES and RHEL 07/10/2017 If you use the Open VMware tools and your applications which depend on VMware APIs fail to start, check SAP Note 2501545.
Incompatibility issues may lead to increased network latency and performance degradation on Windows05/19/2017 If you use Windows Server 2012, 2012 R2 or 2016 guests and you experience an increased rate of “Received Dropped Packets”, check VMware Compatibility Issues may lead to Performance Degradation on Windows.
Update 05/19/2017: VMware published VMware Tools version 10.1.7 which fixes the issue.
VMware NSX for vSphere 6.2.x with ESXi 6.0 P03 10/14/2016
Due to a known issue affecting VMware NSX for vSphere 6.2.x with ESXi 6.0 P03 (Build 4192238) we recommend to consult VMware support before upgrading to the affected combination of products.
See VMware KB article 2146873 for further information.
ESXi 5.5U3 and 6.0: Unpredictable Hangs, Stops, Moves, Crashes of VMs 02/02/2016
After upgrading or installing VMware ESXi 5.5 Update 3 (also U3 versions with letters like U3x) and VMware ESXi 6.0, you encounter unpredictable hangs, stops or moves and crashes of virtual machines. Therefore your SAP application running inside these virtual machines might be interrupted unexpectedly.
Check SAP Note 2237937 for further information.
VMware vSphere 6: Possible Data Corruption 10/14/2015
Backing up a virtual machine with Changed Block Tracking (CBT) enabled fails after upgrading to or installing VMware ESXi 6.0. If you attempt this, you might encounter issues such as:
VMware vSphere 6: Performance Degradation due to High Network Latency 08/09/2016
You are using VMware vSphere 6.0. After changing the virtual machine hardware version to 11, you experience performance degradation of different intensity in network dependent workloads (this includes database access). Every network packet has up to a 0.5 second delay over the expected arrival in the application.
SAP observed a high degree of performance degradation when running SAP systems with MS SQL Server, even if the root cause of this issue is not related to MS SQL Server.
Check SAP Note 2293740 for further information.
Issue in Windows Server 2008 R2 SP1 Guest OS Causing Network Issues 2015
A new Ethernet virtual Network Interface Card (vNIC) may be created with default settings in place of the previously existing vNIC, causing network issues. Any custom settings on the previous vNIC are still persisted in the registry but unused.For details and solutions, see Microsoft KB 3125574.