Many users are facing issue while uploading Excel and few other users are able to upload it without issue. We tried using the same file to upload but still few users are unable to upload the file. Had anyone faced this situation earlier? We are unable to find what is causing the issue. Please help.
Well at least you gave the version details in your question, which many people don't.
Get an error message from what? How are you uploading, to where? Portal, Fiori, SAPGUI, Web Dynpro...?
If some users have a problem and others don't with exactly the same file, then the issue is probably local - either with the local security or maybe SAP authorisations.