You can use Python (from a file or a Jupyter Notebook) to connect to the SAP Datasphere HANA Database. This allows you to send queries, retrieve data, and use it as you wish (e.g., store it in a file, convert it to Excel, send it to a database).
To configure SQL access, you'll need to do it space by space within Space Management (see Integrating Data via Database Users/Open SQL Schemas | SAP Help Portal).
However, if you're asking about using Python Transformation within a Data Flow in SAP Datasphere, then no, that's not possible. Input/output functions are prohibited for Python code executed in DSP Data Flows.
Regads,
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