Chrome 53 has been tested by the SAP test teams with NetWeaver versions 7.02, 7.30, 7.31 and 7.40, Business Suite BS7i2015 and S/4HANA PSE – 1608.
Details about Chrome 53 features can be found in the following link:
http://blog.chromium.org/2016/08/chrome-53-beta-shadow-dom.html
For restrictions and limitations, see the Chrome general note
1655306.